[The disease burden of degenerative mitral valve disease in the Chinese population from 1990 to 2019].

Objective: To explore the trend of disease burden of degenerative mitral valve disease (DMVD) in the Chinese population from 1990 to 2019. Methods: Based on the 2019 Global Burden of Disease database (GBD 2019), the number of patients, the number of new cases, the number of deaths, the disability-adjusted life years (DALY) as well as the prevalence, incidence and death rate, DALY rate and their age-standardized rates were used to analyze the trend of the burden of DMVD in the Chinese population from 1990 to 2019. Results: In 2019, the number of patients, the number of new cases, and the number of deaths with DMVD in China were 461.2, 27.0 and 0.129 ten thousand, respectively, which increased by 209.0%, 199.1% and 13.2% when compared with 1990. In 2019, the age-standardized prevalence, incidence and death rate were 228.1/100 000, 12.7/100 000 and 0.075/100 000, respectively. Compared with 1990, the change of the age-standardized prevalence, incidence and death rate were 32.6%, 42.8% and -54.1%, respectively. In addition, the 2019 data also showed that the age-standardized prevalence and incidence were higher in females than in males (the age-standardized prevalence was 190.1 (181.5-198.9)/100 000 for males and 262.0 (250.3-273.9)/100 000 for females); the age-standardized incidence was 10.5 (10.0-11.0)/100 000 for males and 14.9 (14.3-15.6)/100 000 for females. The age group with the largest number of DMVD patients was 65 to 69 years old, and the highest incidence was 60 to 64 years old. From 1990 to 2019, DALY caused by DMVD showed an upward trend in China, from 46 439 person-years in 1990 to 69 402 person-years in 2019, with an increase of 49.4%. While the age-standardized DALY rate continued to decline, from 5.5/100 000 in 1990 to 3.8/100 000 in 2019, with a drop of 30.8%. The DALY and the age-standardized DALY rate of females were always higher than that of males in different years. Conclusion: From 1990 to 2019, DALY and the age-standardized prevalence and incidence of DMVD in China shows an increasing trend, and the disease burden caused by DMVD is severe in China.目的： 探讨1990至2019年中国人群退行性二尖瓣病变（DMVD）疾病负担变化趋势。 方法： 基于2019年全球疾病负担研究（GBD 2019）数据库，采用患病人数、新发病例数、死亡人数、伤残调整寿命年（DALY）以及患病率、发病率、死亡率、DALY率及其年龄标化率等指标，分析1990至2019年中国人群DMVD疾病负担变化趋势。 结果： 2019年中国DMVD患病人数、新发病例数及死亡人数分别为461.2、27.0、0.129万例，与1990年相比分别增长了209.0%、199.1%和13.2%。2019年DMVD的年龄标化患病率、发病率和死亡率分别为228.1/10万、12.7/10万和0.075/10万，与1990年相比，变化率分别为32.6%、42.8%和-54.1%。另外，2019年的数据还显示，女性的年龄标化患病率和发病率均高于男性［年龄标化患病率：男性190.1（181.5~198.9）/10万、女性262.0（250.3~273.9）/10万；年龄标化发病率：男性10.5（10.0~11.0）/10万、女性14.9（14.3~15.6）/10万］；DMVD患病人数最多的年龄段为65~69岁，而发病率最高的年龄段为60~64岁。1990至2019年，中国因DMVD导致的DALY呈上升趋势，由1990年的4.6万人年升至2019年的6.9万人年，增长了49.4%；而年龄标化DALY率持续下降，由1990年的5.5/10万降至2019年的3.8/10万，降幅30.8%，且女性的DALY和年龄标化DALY率在不同年份均高于男性。 结论： 1990至2019年中国DMVD的DALY及年龄标化患病率、发病率呈持续上升趋势，DMVD所致的疾病负担严峻。.