化学
双功能
磷酸
催化作用
路易斯酸
轴手性
光学活性
组合化学
联氨(抗抑郁剂)
轴对称性
对映选择合成
有机化学
立体化学
药物化学
工程类
结构工程
色谱法
作者
Ya‐Ru Gao,Luo‐Yu Wang,Tao Zhang,Bin‐Miao Yang,Yu Zhao
标识
DOI:10.1002/anie.202200371
摘要
Abstract We present herein a highly efficient atroposelective synthesis of axially chiral 1,1′‐bipyrroles bearing an N−N linkage from simple hydrazine and 1,4‐diones. Further product derivatizations led to axially chiral bifunctional compounds with high potential in asymmetric catalysis. For this chrial phosphoric acid (CPA)‐catalyzed double Paal–Knorr reaction, an intriguing Fe(OTf) 3 ‐induced enantiodivergence was also observed.
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