Research Progress of Nanomaterials for Radioprotection

Radiotherapy is a traditional treatment method that utilizes high-energy radiation to inhibit cancer cells and has been widely used in the treatment of malignant tumors.However, high-energy radiation can not only cause damage to tumors, but also cause side effects to normal tissues.Although some small-molecule radioprotection agents have been used in clinics, their short blood circulation time and faster metabolism greatly reduce the protective effects.In the last twenty years, with the rapid development of nanotechnology in biomedicine, radioprotection nano-agents have provided new candidates for improving the protective effect.Rational design of radioprotection nano-agents is demanded to solve the drawbacks of existing small-molecule radioprotection agents.In view of the many advantages of nanomaterials for radioprotection, this review summarized the common design strategies of nanometer radioprotection materials, and analyzed the pathogenic mechanism of common radiation-induced diseases as well as the treatment of various radiation-induced diseases by radioprotection nano-agents.In addition, this review also discussed the challenges and future prospects of nanomaterial-mediated radioprotection during radiotherapy.