脂质体
生物膜
抗生素
微生物学
胆固醇
生物相容性
药品
化学
药理学
细菌
生物
生物化学
有机化学
遗传学
作者
Jianjun Xie,Zhiping Meng,Xingxing Han,Sipan Li,Xingxing Han,Xuanyu Chen,Yinmei Liang,Xiaomin Deng,Kexin Xia,Yue Zhang,Huaxu Zhu,Tingming Fu
标识
DOI:10.1002/adhm.202101745
摘要
Abstract Resistance and tolerance of biofilms to antibiotics is the greatest challenge in the treatment of bacterial infections. Therefore, developing an effective strategy against biofilms is a top priority. Liposomes are widely used as antibiotic drug carriers; however, common liposomes lack affinity for biofilms. Herein, biofilm‐targeted antibiotic liposomes are created by simply adjusting their cholesterol content. The tailored liposomes exhibit significantly enhanced bacterial inhibition and biofilm eradication effects that are positively correlated with the cholesterol content of liposomes. The experiments further demonstrate that this enhanced effect can be ascribed to the effective drug release through the pores, which are formed by the combination of cholesterol microdomains in liposomal lipid bilayers with membrane‐damaged toxins in biofilms. Consequently, liposome encapsulation with a high cholesterol concentration improves noticeably the pharmacodynamics and biocompatibility of antibiotics after pulmonary administration. This work may provide a new direction for the development of antibiofilm formulations that can be widely used for the treatment of infections caused by bacterial biofilms.
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