生物
冠状病毒
糖蛋白
抗原性
病毒学
多克隆抗体
单克隆抗体
病毒进入
受体
Spike(软件开发)
抗体
病毒
2019年冠状病毒病(COVID-19)
分子生物学
遗传学
病毒复制
传染病(医学专业)
管理
经济
病理
疾病
医学
作者
M. Alejandra Tortorici,Alexandra C. Walls,Anshu Joshi,Young‐Jun Park,Rachel Eguia,Marcos C. Miranda,Elizabeth Kepl,Annie Dosey,Terry Stevens-Ayers,Michael Boeckh,Amalio Telenti,Antonio Lanzavecchia,Neil P. King,Davide Corti,Jesse D. Bloom,David Veesler
出处
期刊:Cell
[Elsevier]
日期:2022-06-01
卷期号:185 (13): 2279-2291.e17
被引量:37
标识
DOI:10.1016/j.cell.2022.05.019
摘要
The isolation of CCoV-HuPn-2018 from a child respiratory swab indicates that more coronaviruses are spilling over to humans than previously appreciated. We determined the structures of the CCoV-HuPn-2018 spike glycoprotein trimer in two distinct conformational states and showed that its domain 0 recognizes sialosides. We identified that the CCoV-HuPn-2018 spike binds canine, feline, and porcine aminopeptidase N (APN) orthologs, which serve as entry receptors, and determined the structure of the receptor-binding B domain in complex with canine APN. The introduction of an oligosaccharide at position N739 of human APN renders cells susceptible to CCoV-HuPn-2018 spike-mediated entry, suggesting that single-nucleotide polymorphisms might account for viral detection in some individuals. Human polyclonal plasma antibodies elicited by HCoV-229E infection and a porcine coronavirus monoclonal antibody inhibit CCoV-HuPn-2018 spike-mediated entry, underscoring the cross-neutralizing activity among ɑ-coronaviruses. These data pave the way for vaccine and therapeutic development targeting this zoonotic pathogen representing the eighth human-infecting coronavirus.
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