Contrast-enhanced CT based radiomics in the preoperative prediction of perineural invasion for patients with gastric cancer

医学 无线电技术 逻辑回归 Lasso(编程语言) 放射科 曼惠特尼U检验 淋巴结 旁侵犯 核医学 癌症 内科学 计算机科学 万维网
作者
Haoze Zheng,Qiao Zheng,Mengmeng Jiang,Ce Han,Jinling Yi,Yao Ai,Congying Xie,Xiance Jin
出处
期刊:European Journal of Radiology [Elsevier]
卷期号:154: 110393-110393 被引量:15
标识
DOI:10.1016/j.ejrad.2022.110393
摘要

To investigate the feasibility and accuracy of radiomics models based on contrast-enhanced CT (CECT) in the prediction of perineural invasion (PNI), so as to stratify high-risk recurrence and improve the management of patients with gastric cancer (GC) preoperatively.Total of 154 GC patients underwent D2 lymph node dissection with pathologically confirmed GC and preoperative CECT from an open-label, investigator-sponsored trial (NCT01711242) were enrolled. Radiomics features were extracted from contoured images and selected using Mann-Whitney U test and the least absolute shrinkage and selection operator (LASSO) after inter-class correlation coefficient (ICC) analysis. Models based on radiomics features (R), clinical factors (C) and combined parameters (R + C) were built and evaluated using Support Vector Machine (SVM) and logistic regression to predict the PNI for patients with GC preoperatively.Total of 11 radiomics features were selected for final analysis, along with two clinical factors. The area under curve (AUC) of models based on R, C, and R + C with logistic regression and SVM were 0.77 vs. 0.83, 0.71 vs.0.70, 0.86 vs. 0.90, and 0.73 vs.0.80, 0.62 vs. 0.64, 0.77 vs. 0.82 in the training and testing cohorts, respectively. SVM(R + C) achieved a best AUC of 0.82(0.69-0.94) in the test cohorts with a sensitivity, specificity and accuracy of 0.63, 0.91, and 0.77, respectively.The performance of these models indicates that radiomics features alone or combined with clinical factors provide a feasible way to classify patients preoperatively and improve the management of patients with GC.
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