医学
肌萎缩
无线电技术
正电子发射断层摄影术
阶段(地层学)
癌症
腺癌
食管癌
放射科
内科学
肿瘤科
古生物学
生物
作者
Reut Anconina,Claudia Ortega,Ur Metser,Zhihui Amy Liu,Elena Elimova,Michael J. Allen,Gail Darling,Rebecca Wong,Kirsty Taylor,Jonathan Yeung,Eric X. Chen,Carol J. Swallow,Raymond Woo-Jun Jang,Patrick Veit‐Haibach
出处
期刊:Clinical Nuclear Medicine
[Ovid Technologies (Wolters Kluwer)]
日期:2022-05-11
卷期号:47 (8): 684-691
被引量:18
标识
DOI:10.1097/rlu.0000000000004253
摘要
Purpose The aim of this study was to determine if radiomic features combined with sarcopenia measurements on pretreatment 18 F-FDG PET/CT can improve outcome prediction in surgically treated adenocarcinoma esophagogastric cancer patients. Patients and Methods One hundred forty-five esophageal adenocarcinoma patients with curative therapeutic intent and available pretreatment 18 F-FDG PET/CT were included. Textural features from PET and CT images were evaluated using LIFEx software (lifexsoft.org). Sarcopenia measurements were done by measuring the Skeletal Muscle Index at L3 level on the CT component. Univariable and multivariable analyses were conducted to create a model including the radiomic parameters, clinical features, and Skeletal Muscle Index score to predict patients’ outcome. Results In multivariable analysis, we combined clinicopathological parameters including ECOG, surgical T, and N staging along with imaging derived sarcopenia measurements and radiomic features to build a predictor model for relapse-free survival and overall survival. Overall, adding sarcopenic status to the model with clinical features only (likelihood ratio test P = 0.03) and CT feature ( P = 0.0037) improved the model fit for overall survival. Similarly, adding sarcopenic status ( P = 0.051), CT feature ( P = 0.042), and PET feature ( P = 0.011) improved the model fit for relapse-free survival. Conclusions PET and CT radiomics derived from combined PET/CT integrated with clinicopathological parameters and sarcopenia measurement might improve outcome prediction in patients with nonmetastatic esophagogastric adenocarcinoma.
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