自愈水凝胶
化学
纳米纤维
两亲性
超分子化学
肽
寄主(生物学)
纳米技术
组合化学
高分子化学
分子
有机化学
生物化学
共聚物
聚合物
生物
生态学
材料科学
作者
Carlos Redondo-Gómez,Soraya Padilla-Lopátegui,Álvaro Mata,Helena S. Azevedo
标识
DOI:10.1021/acs.bioconjchem.1c00441
摘要
Supramolecular hydrogels based on peptide amphiphiles (PAs) are promising materials for tissue engineering and model extracellular matrixes for biological studies. While PA hydrogels are conventionally formed via electrostatic screening, new hydrogelation mechanisms might help to improve the design and functionality of these materials. Here, we present a host-guest-mediated PA hydrogelation method that relies on the formation of a host-guest homoternary complex with cucurbit[8]uril (CB[8]) and aromatic amino-acid-bearing PA nanofibers. As a result of the host-guest cross-linking between PA nanofibers, hierarchical morphologies and increased stiffness were found when host-guest-mediated PA hydrogels were compared to their ion-based equivalents. Additionally, both families of hydrogels exhibited similar biocompatibilities. These results demonstrate that CB[8]-mediated hydrogelation can be used as an alternative cross-linking method to upgrade the design of PA materials and extend their biomedical applications.
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