巴比妥酸
精神分裂症(面向对象编程)
犬尿氨酸
阳性与阴性症状量表
代谢物
内科学
医学
外围设备
生物标志物
毒品天真
精神科
药品
精神病
色氨酸
化学
敌手
受体
氨基酸
生物化学
作者
Wenhua Ding,Fengchun Wu,Sumiao Zhou,Hehua Li,Runhua Wang,Yuping Ning
标识
DOI:10.1080/08039488.2021.1992647
摘要
Kynurenic acid (KYNA) is a metabolite of tryptophan (TRP). KYNA levels have been reported with controversial findings in patients with schizophrenia.This study aimed to investigate the probable effects of medication and illness chronicity on peripheral KYNA levels in schizophrenia.We assessed peripheral (plasma) TRP metabolite levels in 38 drug-free patients with first-episode schizophrenia (FES), 65 patients with chronic schizophrenia (CHS), and 70 healthy controls by using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The symptom severity of patients was evaluated by using the Positive and Negative Syndrome Scale (PANSS). Finally, we analyzed the association of TRP metabolites with symptom severity.We found significantly higher KYNA levels in FES patients than in both healthy controls (p < 0.01) and CHS patients (p < 0.05). No significant association was observed between plasma TRP metabolite levels and PANSS scores in either FES or CHS patients.In conclusion, elevated plasma KYNA levels may be a promising biomarker in FES patients. Medication and illness chronicity may affect peripheral KYNA levels with a currently unknown mechanism.
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