内科学
内分泌学
医学
神经退行性变
氧化应激
自动调节
协同运输机
血压
钠
化学
疾病
有机化学
作者
Shaoxun Wang,Feng Jiao,Jane J. Border,Xing Fang,Reece F. Crumpler,Yedan Liu,Shouxin Zhang,Joshua R. Jefferson,Ya Guo,P. Elliott,Kirby N. Thomas,Luke Strong,Austin H. Urvina,Baoying Zheng,Arjun Hari Rijal,Stanley V. Smith,Hongwei Yu,Richard J. Roman,Fan Fan
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physiological Society]
日期:2021-12-24
卷期号:322 (2): H246-H259
被引量:20
标识
DOI:10.1152/ajpheart.00438.2021
摘要
This study demonstrates that luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, improved CBF autoregulation in association with reduced vascular oxidative stress and AGEs production in the cerebrovasculature of 18-mo-old DM rats. SGLT2i also prevented BBB leakage, impaired functional hyperemia, neurodegeneration, and cognitive impairment seen in DM rats. Luseogliflozin did not have direct constrictive effects on VSMCs and MCAs isolated from normal rats. These results provide evidence that normalization of hyperglycemia with an SGLT2i can reverse cerebrovascular dysfunction and cognitive impairments in rats with long-standing hyperglycemia, possibly by ameliorating oxidative stress-caused vascular damage.
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