Highlights of the Recent Patent Literature: Focus on Asymmetric Organocatalysis

This review explores contributions in asymmetric organocatalysis from the patent literature since 2018, including reactions catalyzed by Cinchona alkaloids as free base and quaternary salts, phosphonium salts, proline-derived catalysts, and chiral phosphoric acids. Examples of processes employing asymmetric organocatalysis for the industrial preparation of pharmaceutical intermediates are highlighted.