Recent updates on the stereoselective synthesis of structurally functionalized spiro-oxindoles mediated by isatin N, N´‑cyclic azomethine imine 1, 3-dipoles

Spirooxindoles are frequently encountered in the basic skeleton of a diverse range of natural alkaloids and therapeutically significant molecules. Consequently, the developments of elegant synthetic methods for the assembly of these motifs are extremely demanding but challenging. On the other hand, the utilization of isatin N, N′-cyclic azomethine imines which is a new type of stable azomethine imines, in 1,3-dipolar cycloaddition, Michael addition and α-alkylation reaction for the preparation of carbon–carbon, and structurally functionalized heterocyclic compounds have been studied but still underdeveloped. In this digest, the developments achieved regarding the construction of spirooxindoles mediated by isatin N, N′-cyclic azomethine imines have been disclosed.