Metabolic exchanges between the oocyte and its environment: focus on lipids.

卵母细胞 卵泡液 细胞生物学 生物 脂质代谢 脂类学 卵泡 卵泡期 毛囊 卵子发生
作者
Svetlana Uzbekova,Priscila Silvana Bertevello,Rozenn Dalbies-Tran,Sebastien Elis,Valerie Labas,Philippe Monget,Ana-Paula Teixeira-Gomes
出处
期刊:Reproduction, Fertility and Development [CSIRO Publishing]
卷期号:34 (2): 1-26
标识
DOI:10.1071/rd21249
摘要

Finely regulated fatty acid (FA) metabolism within ovarian follicles is crucial to follicular development and influences the quality of the enclosed oocyte, which relies on the surrounding intra-follicular environment for its growth and maturation. A growing number of studies have examined the association between the lipid composition of follicular compartments and oocyte quality. In this review, we focus on lipids, their possible exchanges between compartments within the ovarian follicle and their involvement in different pathways during oocyte final growth and maturation. Lipidomics provides a detailed snapshot of the global lipid profiles and identified lipids, clearly discriminating the cells or fluid from follicles at distinct physiological stages. Follicular fluid appears as a main mediator of lipid exchanges between follicular somatic cells and the oocyte, through vesicle-mediated and non-vesicular transport of esterified and free FA. A variety of expression data allowed the identification of common and cell-type-specific actors of lipid metabolism in theca cells, granulosa cells, cumulus cells and oocytes, including key regulators of FA uptake, FA transport, lipid transformation, lipoprotein synthesis and protein palmitoylation. They act in harmony to accompany follicular development, and maintain intra-follicular homeostasis to allow the oocyte to accumulate energy and membrane lipids for subsequent meiotic divisions and first embryo cleavages.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
阿典完成签到,获得积分10
刚刚
lilala发布了新的文献求助10
1秒前
H_C发布了新的文献求助10
1秒前
瀚森完成签到 ,获得积分10
2秒前
罗亚亚完成签到,获得积分10
3秒前
小二郎应助俊逸的代曼采纳,获得10
4秒前
赤子白仙完成签到,获得积分10
5秒前
5秒前
星忆眠完成签到,获得积分10
5秒前
整齐的泥猴桃完成签到,获得积分10
5秒前
小蘑菇应助林夕采纳,获得10
6秒前
19完成签到,获得积分10
6秒前
7秒前
直率的宛海完成签到,获得积分10
8秒前
酷炫葵阴完成签到,获得积分10
8秒前
叶未晞yi完成签到,获得积分10
8秒前
灵巧妙芙完成签到,获得积分10
9秒前
ania完成签到,获得积分10
9秒前
10秒前
苦哈哈完成签到,获得积分0
11秒前
情红锐完成签到,获得积分10
11秒前
潜山耕之完成签到,获得积分10
11秒前
12秒前
12秒前
闪闪落雁发布了新的文献求助10
13秒前
善良的火发布了新的文献求助30
13秒前
keroro完成签到,获得积分10
13秒前
十一完成签到 ,获得积分10
13秒前
14秒前
打打应助Xue采纳,获得10
14秒前
carm小蛋黄发布了新的文献求助10
14秒前
天天看文献完成签到,获得积分10
15秒前
火云应助林晓筱采纳,获得20
15秒前
清晨之风发布了新的文献求助10
15秒前
Anna发布了新的文献求助10
16秒前
波鲁鲁爱喝酸奶完成签到 ,获得积分10
16秒前
yiluyouni完成签到,获得积分10
16秒前
好远的梦发布了新的文献求助10
16秒前
街角发布了新的文献求助10
18秒前
晚庭落秋风完成签到 ,获得积分10
18秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
A Dissection Guide & Atlas to the Rabbit 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3081823
求助须知:如何正确求助?哪些是违规求助? 2734862
关于积分的说明 7534680
捐赠科研通 2384387
什么是DOI,文献DOI怎么找? 1264312
科研通“疑难数据库(出版商)”最低求助积分说明 612614
版权声明 597600