Potential obesogenic effects of TBBPA and its alternatives TBBPS and TCBPA revealed by metabolic perturbations in human hepatoma cells

四溴双酚A 毒性 化学 生物化学 生物 内分泌学 药理学 内科学 医学 有机化学 阻燃剂
作者
Yunjiang Yu,Chaojie Hao,Mingdeng Xiang,Jinglin Tian,Hongxuan Kuang,Zhenchi Li
出处
期刊:Science of The Total Environment [Elsevier]
卷期号:832: 154847-154847 被引量:16
标识
DOI:10.1016/j.scitotenv.2022.154847
摘要

To date, increasing numbers of studies have shown the obesogenic effects of tetrabromobisphenol A (TBBPA). Tetrabromobisphenol S (TBBPS) and tetrachlorobisphenol A (TCBPA) are two common alternatives to TBBPA, and their environmental distributions are frequently reported. However, their toxicity and the associated potential health risks are poorly documented. Herein, we performed untargeted metabolomics to study the metabolic perturbations in HepG2 cells exposed to TBBPA and its alternatives. Consequently, no loss of cellular viability was observed in HepG2 cells exposed to 0.1 μmol/L and 1 μmol/L TBBPA, TBBPS and TCBPA. However, multivariate analysis and metabolic profiles revealed significant perturbations in glycerophospholipid and fatty acyl levels in HepG2 cells exposure to TBBPS and TCBPA. The evident increases in the glucose 1-phosphate and fructose 6-phosphate levels in HepG2 cells were proposed to be induced by the promotion of PGM1/PGM2 and GPI gene expression and the suppression of UPG2 and GFPT1/GFPT2 gene expression. Our results suggest that TBBPS and TCBPA are more likely to disrupt liver metabolic homeostasis and potentially drive liver dysfunction than TBBPA. Our study is significant for the re-evaluation of the health risks associated with TBBPA and its alternatives TBBPS and TCBPA.
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