菁
荧光
谷胱甘肽
荧光寿命成像显微镜
部分
体内
分子探针
细胞内
生物物理学
化学
光学
生物
生物化学
立体化学
DNA
物理
生物技术
酶
作者
Da‐Young Lee,Ki‐Hun Jeong,Xiao Luo,Gayoung Kim,Youjun Yang,Xiaoqiang Chen,Sehoon Kim,Juyoung Yoon
摘要
Two new cyanine-based fluorescent probes 1 and 2 have been developed. Probe 1 bears two cyanine units in a single molecule, and probe 2 contains a bis(trifluoromethyl)benzenethiol moiety. Both are non-fluorescent. The addition of intracellular glutathione (GSH) significantly enhanced the NIR fluorescence of the two probes. Both probes were used to image varying amounts of GSH in living cells. In tumor bearing mice, the in vivo fluorescence intensity of both probes was higher in tumors, where GSH is overexpressed, than in normal tissues. These results suggest that these new fluorogenic probes have potential for GSH-targeting diagnostic imaging.
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