Plasma stem cell factor levels are associated with risk of cardiovascular disease and death

医学 内科学 四分位数 危险系数 风险因素 心肌梗塞 比例危险模型 人口 冲程(发动机) 心力衰竭 内分泌学 心脏病学 肿瘤科 置信区间 工程类 环境卫生 机械工程
作者
Harry Björkbacka,Ingrid Yao Mattisson,Maria Wigren,Olle Melander,Gunilla Nordin Fredrikson,Eva Bengtsson,Isabel Gonçalves,Peter Almgren,Jens O. Lagerstedt,Marju Orho‐Melander,Gunnar Engström,Jan Nilsson
出处
期刊:Journal of Internal Medicine [Wiley]
卷期号:282 (6): 508-521 被引量:34
标识
DOI:10.1111/joim.12675
摘要

Stem cell factor (SCF) is a key growth factor for several types of stem and progenitor cells. There is experimental evidence that such cells are of importance for maintaining the integrity of the cardiovascular system. We investigated the association between circulating levels of SCF and risk for development of cardiovascular events and death.SCF was analysed by the proximity extension assay technique in plasma from 4742 subjects participating in the Malmö Diet and Cancer Study. Cardiovascular events and death were monitored through national registers with a mean follow-up time of 19.2 years.Subjects with high baseline levels of SCF had lower cardiovascular (n = 340) and all-cause mortality (n = 1159) as well as a lower risk of heart failure (n = 177), stroke (n = 318) and myocardial infarction (n = 452). Smoking, diabetes and high alcohol consumption were associated with lower levels of SCF. Single nucleotide polymorphisms in the gene region encoding PDX1 C-terminal inhibiting factor 1 (PCIF1) and matrix metalloproteinase-9 were associated with plasma SCF levels. The highest SCF quartile remained independently associated with a lower risk of a lower risk of cardiovascular [hazard ratio and 95% confidence interval 0.59 (0.43-0.81)] and all-cause mortality [0.68 (0.57-0.81)], heart failure [0.50 (0.31-0.80)] and stroke [0.66 (0.47-0.92)], but not with MI [0.96 (0.72-1.27)] as compared with the lowest quartile when adjusting for traditional cardiovascular risk factors in Cox proportional hazard regression models.This prospective population-based study demonstrates that subjects with high levels of SCF have a lower risk of cardiovascular events and death. The findings provide clinical support for a protective role of SCF in maintaining cardiovascular integrity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
R2L23发布了新的文献求助10
1秒前
1秒前
诚心的扬发布了新的文献求助10
2秒前
3秒前
liupc2019完成签到,获得积分10
4秒前
顾矜应助momo采纳,获得10
5秒前
周em12_发布了新的文献求助10
5秒前
6秒前
7秒前
7秒前
FashionBoy应助ZZZ采纳,获得10
8秒前
10秒前
清爽傲云发布了新的文献求助10
12秒前
12秒前
14秒前
16秒前
嗨嗨害发布了新的文献求助10
16秒前
Eileen发布了新的文献求助10
17秒前
呵呵哒发布了新的文献求助10
20秒前
清爽傲云完成签到,获得积分10
22秒前
22秒前
23秒前
momo发布了新的文献求助10
27秒前
诚心的扬关注了科研通微信公众号
28秒前
30秒前
嗨嗨害完成签到,获得积分10
31秒前
吧啦吧啦完成签到,获得积分10
31秒前
32秒前
33秒前
zero完成签到,获得积分10
34秒前
小二郎应助momo采纳,获得10
35秒前
hh完成签到 ,获得积分10
35秒前
大大完成签到 ,获得积分10
35秒前
35秒前
量子星尘发布了新的文献求助10
37秒前
YI发布了新的文献求助10
37秒前
Stardust完成签到 ,获得积分10
38秒前
zero发布了新的文献求助10
38秒前
共享精神应助果粒多采纳,获得10
39秒前
ali应助史念薇采纳,获得10
41秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989297
求助须知:如何正确求助?哪些是违规求助? 3531418
关于积分的说明 11253893
捐赠科研通 3270097
什么是DOI,文献DOI怎么找? 1804884
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809158