Quality of life after brachytherapy or bilateral nerve‐sparing robot‐assisted radical prostatectomy for prostate cancer: a prospective cohort

Objective To provide comparative data on quality of life (QoL) after prostate cancer treatment to help patients make an informed decision regarding their choice of treatment. Methods Patients with pathologically proven, non‐metastatic, T1–T3bN0 prostate cancer were included in this prospective non‐randomized study if they were to receive treatment with curative intent. Sample size was at least 181 patients per cohort/treatment type. QoL was recorded at baseline and at each follow‐up using the Expanded Prostate Cancer Index Composite ( EPIC ) instrument. The minimal clinically important difference was defined as half of the standard deviation of the baseline score for each domain. A mixed effects model was used to compare the different treatments. Data are presented on the brachytherapy and the bilateral nerve‐sparing robot‐assisted radical prostatectomy ( RARP ) cohorts. Hormonotherapy was not allowed. Results Between November 2007 and January 2013, 181 patients who received brachytherapy and 210 patients who underwent RARP were included. Of the patients who underwent RARP , 178 had bilateral nerve‐sparing and were included in the present analysis. Response rate to EPIC questionnaires were higher in the brachytherapy than in the RARP arm: 82% vs 57% at 2 years after treatment and 55% vs 45% at 4 years after treatment. In the mixed effects model, patients in the RARP arm had better QoL with regard to urinary irritation/obstruction or bother and bowel function, and lower QoL regarding sexual function and urinary incontinence. Results were confirmed in a propensity score‐matched model. Patient satisfaction was significantly higher in the brachytherapy group at 1, 2 and 3 years after treatment. Conclusion This prospective non‐randomized study shows long‐term differences in QoL domains after bilateral nerve‐sparing RARP and brachytherapy. Differences in patient satisfaction should be further explored. These results could be used to counsel patients in the decision‐making process.