医学
炎症
疾病
机制(生物学)
背景(考古学)
风险因素
内科学
因果关系(物理学)
人口
慢性应激
心理干预
冠心病
生物信息学
精神科
物理
哲学
古生物学
认识论
环境卫生
生物
量子力学
作者
Petra H. Wirtz,Roland von Känel
标识
DOI:10.1007/s11886-017-0919-x
摘要
In this review, we summarize evidence on the risk factor psychological stress in the context of coronary heart disease (CHD) in humans and explore the role of inflammation as a potential underlying mechanism. While chronic stress increases the risk of incident CHD and poor cardiovascular prognosis, acute emotional stress can trigger acute CHD events in vulnerable patients. Evidence supporting a potential role for inflammation as a promising biological mechanism comes from population-based studies showing associations between chronic stress and increased inflammation. Similarly, experimental studies demonstrate acute stress-induced increases in inflammatory markers and suggest modulatory potential for pharmacological and biobehavioral interventions. So far, studies investigating patients with cardiovascular disease are few and the full sequence of events from stress to inflammation to CHD remains to be established. Psychological stress is an independent CHD risk factor associated with increased inflammation. Although promising, causality needs to be further explored.
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