Toward a Comprehensive Delineation of White Matter Tract-Related Deformation

纤维束 拉伤 脑震荡 变形(气象学) 无穷小应变理论 白质 医学 解剖 材料科学 结构工程 毒物控制 有限元法 放射科 复合材料 磁共振成像 工程类 伤害预防 环境卫生
作者
Zhou Zhou,Xiaogai Li,Yuzhe Liu,Madelen Fahlstedt,Marios Georgiadis,Xianghao Zhan,Samuel Raymond,Gerald A. Grant,Svein Kleiven,David B. Camarillo,Michael Zeineh
出处
期刊:Journal of Neurotrauma [Mary Ann Liebert, Inc.]
卷期号:38 (23): 3260-3278 被引量:25
标识
DOI:10.1089/neu.2021.0195
摘要

Finite element (FE) models of the human head are valuable instruments to explore the mechanobiological pathway from external loading, localized brain response, and resultant injury risks. The injury predictability of these models depends on the use of effective criteria as injury predictors. The FE-derived normal deformation along white matter (WM) fiber tracts (i.e., tract-oriented strain) recently has been suggested as an appropriate predictor for axonal injury. However, the tract-oriented strain only represents a partial depiction of the WM fiber tract deformation. A comprehensive delineation of tract-related deformation may improve the injury predictability of the FE head model by delivering new tract-related criteria as injury predictors. Thus, the present study performed a theoretical strain analysis to comprehensively characterize the WM fiber tract deformation by relating the strain tensor of the WM element to its embedded fiber tract. Three new tract-related strains with exact analytical solutions were proposed, measuring the normal deformation perpendicular to the fiber tracts (i.e., tract-perpendicular strain), and shear deformation along and perpendicular to the fiber tracts (i.e., axial-shear strain and lateral-shear strain, respectively). The injury predictability of these three newly proposed strain peaks along with the previously used tract-oriented strain peak and maximum principal strain (MPS) were evaluated by simulating 151 impacts with known outcome (concussion or non-concussion). The results preliminarily showed that four tract-related strain peaks exhibited superior performance than MPS in discriminating concussion and non-concussion cases. This study presents a comprehensive quantification of WM tract-related deformation and advocates the use of orientation-dependent strains as criteria for injury prediction, which may ultimately contribute to an advanced mechanobiological understanding and enhanced computational predictability of brain injury.
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