细胞代谢
结肠炎
生物
程序性细胞死亡
细胞生物学
糖酵解
己糖激酶
线粒体
细胞凋亡
新陈代谢
生物化学
免疫学
作者
Finn Hinrichsen,Jacob Hamm,Magdalena Westermann,Lena Schröder,Kensuke Shima,Neha Mishra,Alesia Walker,Nina Sommer,Kenneth Klischies,Daniela Prasse,Johannes Zimmermann,Sina Kaiser,Dora Bordoni,Antonella Fazio,Γεώργιος Μαρίνος,Georg Laue,Simon Imm,Valentina Tremaroli,Marijana Basic,Robert Häsler
出处
期刊：Cell Metabolism
[Elsevier]
日期：2021-11-29
卷期号：33 (12): 2355-2366.e8
被引量：91
标识
DOI：10.1016/j.cmet.2021.11.004
摘要
Hexokinases (HK) catalyze the first step of glycolysis limiting its pace. HK2 is highly expressed in gut epithelium, contributes to immune responses, and is upregulated during inflammation. We examined the microbial regulation of HK2 and its impact on inflammation using mice lacking HK2 in intestinal epithelial cells (Hk2
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