作者
Finn Hinrichsen,Jacob Hamm,Magdalena Westermann,Lena Schröder,Kensuke Shima,Neha Mishra,Alesia Walker,Nina Sommer,Kenneth Klischies,Daniela Prasse,Johannes Zimmermann,Sina Kaiser,Dora Bordoni,Antonella Fazio,Γεώργιος Μαρίνος,Georg Laue,Simon Imm,Valentina Tremaroli,Marijana Basic,Robert Häsler,Ruth A. Schmitz,Stefan Krautwald,Andrea J. Wolf,Bärbel Stecher,Philippe Schmitt‐Kopplin,Christoph Kaleta,Jan Rupp,Fredrik Bäckhed,Philip Rosenstiel,Felix Sommer
摘要
Hexokinases (HK) catalyze the first step of glycolysis limiting its pace. HK2 is highly expressed in gut epithelium, contributes to immune responses, and is upregulated during inflammation. We examined the microbial regulation of HK2 and its impact on inflammation using mice lacking HK2 in intestinal epithelial cells (Hk2
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