Marine algal flavonoids and phlorotannins; an intriguing frontier of biofunctional secondary metabolites

Algae are the oldest representatives of the plant world with reserves exceeding hundreds of millions of tons in the world's oceans. Currently, a growing interest is placed toward the use of algae as feedstocks for obtaining numerous natural products. Algae are a rich source of polyphenols that possess intriguing structural diversity. Among the algal polyphenols, phlorotannins, which are unique to brown seaweeds, and have immense value as potent modulators of biochemical processes linked to chronic diseases. In algae, flavonoids remain under-explored compared to other categories of polyphenols. Both phlorotannins and flavonoids are inclusive of compounds indicating a wide structural diversity. The present paper reviews the literature on the ecological significance, biosynthesis, structural diversity, and bioactivity of seaweed phlorotannins and flavonoids. The potential implementation of these chemical entities in functional foods, cosmeceuticals, medicaments, and as templates in drug design are described in detail, and perspectives are provided to tackle what are perceived to be the most momentous challenges related to the utilization of phlorotannins and flavonoids. Moving beyond: industrial biotechnology applications, metabolic engineering, total synthesis, biomimetic synthesis, and chemical derivatization of phlorotannins and flavonoids could broaden the research perspectives contributing to the health and economic up-gradation.