衰老
心脏纤维化
氧化应激
细胞生物学
老化
自噬
表观遗传学
心肌细胞
医学
生物
纤维化
端粒
病理
内分泌学
遗传学
细胞凋亡
基因
作者
Maggie Chen,Richard Lee,Jessica C. Garbern
出处
期刊:Cardiovascular Research
[Oxford University Press]
日期:2021-05-08
卷期号:118 (5): 1173-1187
被引量:125
摘要
Abstract Cellular senescence is a state of irreversible cell cycle arrest associated with ageing. Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular diseases (CVDs) such as atherosclerosis, myocardial infarction, and cardiac fibrosis. While age-related telomere shortening represents a major cause of replicative senescence, the senescent state can also be induced by oxidative stress, metabolic dysfunction, and epigenetic regulation, among other stressors. It is critical that we understand the molecular pathways that lead to cellular senescence and the consequences of cellular senescence in order to develop new therapeutic approaches to treat CVD. In this review, we discuss molecular mechanisms of cellular senescence, explore how cellular senescence of different cardiac cell types (including cardiomyocytes, cardiac endothelial cells, cardiac fibroblasts, vascular smooth muscle cells, and valve interstitial cells) can lead to CVD, and highlight potential therapeutic approaches that target molecular mechanisms of cellular senescence to prevent or treat CVD.
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