蛋白激酶B
AKT2型
AKT1型
PI3K/AKT/mTOR通路
癌症研究
AKT3
乳腺癌
原癌基因蛋白质c-akt
基因亚型
激酶
信号转导
癌症
生物
医学
肿瘤科
细胞生物学
癌细胞
PTEN公司
内科学
细胞生长
生物化学
遗传学
基因
作者
Alakananda Basu,Christoffer Lambring
出处
期刊:Cancers
[MDPI AG]
日期:2021-07-09
卷期号:13 (14): 3445-3445
被引量:29
标识
DOI:10.3390/cancers13143445
摘要
Akt, also known as protein kinase B (PKB), belongs to the AGC family of protein kinases. It acts downstream of the phosphatidylinositol 3-kinase (PI3K) and regulates diverse cellular processes, including cell proliferation, cell survival, metabolism, tumor growth and metastasis. The PI3K/Akt signaling pathway is frequently deregulated in breast cancer and plays an important role in the development and progression of breast cancer. There are three closely related members in the Akt family, namely Akt1(PKBα), Akt2(PKBβ) and Akt3(PKBγ). Although Akt isoforms share similar structures, they exhibit redundant, distinct as well as opposite functions. While the Akt signaling pathway is an important target for cancer therapy, an understanding of the isoform-specific function of Akt is critical to effectively target this pathway. However, our perception regarding how Akt isoforms contribute to the genesis and progression of breast cancer changes as we gain new knowledge. The purpose of this review article is to analyze current literatures on distinct functions of Akt isoforms in breast cancer.
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