血管生成
伤口愈合
膜
体内
纳米纤维
肉芽组织
炎症
细胞生物学
细胞外基质
基质金属蛋白酶
血管内皮生长因子
材料科学
化学
生物医学工程
纳米技术
癌症研究
生物化学
医学
免疫学
血管内皮生长因子受体
生物
生物技术
作者
Atta ur Rehman Khan,Kai Huang,Mina Shahriari‐Khalaji,Yu Fan,Xianrui Xie,Tonghe Zhu,Yosry Morsi,Jinzhong Zhao,Xiumei Mo
标识
DOI:10.1016/j.bioactmat.2021.01.040
摘要
Diabetic wound (DW) healing is a major clinical challenge due to multifactorial complications leading to prolonged inflammation. Electrospun nanofibrous (NF) membranes, due to special structural features, are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled manner. Herein, we report a multifunctional composite NF membrane loaded with ZnO nanoparticles (NP) and oregano essential oil (OEO), employing a new loading strategy, capable to sustainedly co-deliver bioactive agents. Physicochemical characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant activities. Furthermore, in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue formation. The angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor (VEGF). Moreover, the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin −6 (IL-6) and matrix metalloproteinases-9 (MMP-9). In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW.
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