伤口愈合
血管生成
体内
壳聚糖
辛伐他汀
Zeta电位
药理学
体外
生物医学工程
糖尿病
材料科学
纳米颗粒
四氧嘧啶
化学
核化学
纳米技术
医学
外科
癌症研究
生物化学
生物技术
内分泌学
生物
作者
Muhammad Irfan Siddique,Saima Tufail,Muhammad Sarfraz,Muhammad Sohail,Muhammad Nabeel Shahid,Muhammad Ovais Omer,Haliza Katas,Fatima Rasool
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2021-07-21
卷期号:19 (5): 534-546
被引量:6
标识
DOI:10.2174/1567201818666210720150929
摘要
The pleiotropic effects of statins are recently explored for wound healing through angiogenesis and lymph-angiogenesis that could be of great importance in diabetic wounds.The aim of the present study is to fabricate nanofilm embedded with simvastatin-loaded chitosan nanoparticles (CS-SIM-NPs) and to explore the efficacy of SIM in diabetic wound healing.The NPs, prepared via ionic gelation, were 173 nm ± 2.645 in size with a zeta potential of -0.299 ± 0.009 and PDI 0.051 ± 0.088 with excellent encapsulation efficiency (99.97%). The optimized formulation (CS: TPP, 1:1) that exhibited the highest drug release (91.64%) was incorporated into the polymeric nanofilm (HPMC, Sodium alginate, PVA), followed by in vitro characterization. The optimized nanofilm was applied to the wound created on the back of diabetes-induced (with alloxan injection 120 mg/kg) albino rats.The results showed a significant (p < 0.05) improvement in the wound healing process compared to the diabetes-induced non-treated group. The results highlighted the importance of nanofilms loaded with SIM-NPs in diabetic wound healing through angiogenesis promotion at the wound site.Thus, CS-SIM-NPs loaded polymeric nanofilms could be an emerging diabetic wound healing agent in the industry of nanomedicines.
科研通智能强力驱动
Strongly Powered by AbleSci AI