诺氟沙星
化学
抗菌活性
电喷雾电离
对接(动物)
核化学
三唑
组合化学
质谱法
立体化学
细菌
生物化学
有机化学
色谱法
抗生素
医学
生物
护理部
环丙沙星
遗传学
作者
Ping Yang,Jiabao Luo,Xiaogang Wang,Lilei Zhang,Feng Jin,Xiao‐Bao Xie,Qingshan Shi,Xinguo Zhang
标识
DOI:10.1016/j.bioorg.2021.105270
摘要
A series of 1,2,4-triazole-norfloxacin hybrids was designed, synthesized, and evaluated for in vitro antibacterial activity against common pathogens. All the newly synthesized compounds were characterized by Fourier-transform infrared spectrophotometry, proton and carbon nuclear magnetic resonance, and electrospray ionization-mass spectrometry. Representative compounds from each step of the synthesis were further characterized by X-ray crystallography. Many of the compounds synthesized exhibited antibacterial activity superior to that of norfloxacin toward both, gram-positive and gram-negative bacteria. The toxicity of the 1,2,4-triazole-norfloxacin hybrids toward bacterial cells was 32-512 times higher than that toward mouse fibroblast cells. Moreover, hemolysis was not observed at concentrations of 64 μg/mL, suggesting good biocompatibility. Molecular docking showed a least binding energy of -9.4 to -9.7 kcal/mol, and all compounds were predicted to show remarkable affinity for the bacterial topoisomerase IV.
科研通智能强力驱动
Strongly Powered by AbleSci AI