小胶质细胞
炎症
间充质干细胞
免疫系统
神经科学
细胞生物学
医学
神经营养因子
背景(考古学)
微泡
小RNA
免疫学
生物
基因
受体
生物化学
古生物学
内科学
作者
Xinyu Yang,Wei Wei,Yongli Pan,Baolong Cui,Xinyu Yang,Mathias Bähr,Thorsten R. Doeppner
出处
期刊:World Journal of Stem Cells
[Baishideng Publishing Group Co (World Journal of Stem Cells)]
日期:2021-08-19
卷期号:13 (8): 1030-1048
被引量:19
标识
DOI:10.4252/wjsc.v13.i8.1030
摘要
Inflammation plays an important role in the pathological process of ischemic stroke, and systemic inflammation affects patient prognosis.As resident immune cells in the brain, microglia are significantly involved in immune defense and tissue repair under various pathological conditions, including cerebral ischemia.Although the differentiation of M1 and M2 microglia is certainly oversimplified, changing the activation state of microglia appears to be an intriguing therapeutic strategy for cerebral ischemia.Recent evidence indicates that both mesenchymal stem cells (MSCs) and MSC-derived extracellular vesicles (EVs) regulate inflammation and modify tissue repair under preclinical stroke conditions.However, the precise mechanisms of these signaling pathways, especially in the context of the mutual interaction between MSCs or MSC-derived EVs and resident microglia, have not been sufficiently unveiled.Hence, this review summarizes the state-ofthe-art knowledge on MSC-and MSC-EV-mediated regulation of microglial activity under ischemic stroke conditions with respect to various signaling pathways, including cytokines, neurotrophic factors, transcription factors, and microRNAs.
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