肝星状细胞
衰老
细胞外基质
细胞衰老
肝纤维化
细胞生物学
效应器
纤维化
生物
细胞
肝纤维化
癌症研究
病理
医学
生物化学
表型
基因
内分泌学
作者
Sandra Serna Salas,Abel Soto-Gamez,Zongmei Wu,Myrthe Klaver,Han Moshage
出处
期刊:Methods in molecular biology
日期:2023-01-01
卷期号:: 79-109
被引量:1
标识
DOI:10.1007/978-1-0716-3207-9_6
摘要
Hepatic stellate cells (HSCs) are the key effector cells in liver fibrosis. They are the main producers of excessive amounts of extracellular matrix components during fibrogenesis and therefore a potential target for the treatment of liver fibrosis. Induction of senescence in HSCs may be a promising strategy to slow down, stop, or even reverse fibrogenesis. Senescence is a complex and heterogeneous process linked to fibrosis and cancer, but the exact mechanism and relevant markers can be cell-type dependent. Therefore, many markers of senescence have been proposed, and many methods to detect senescence have been developed. In this chapter, we review relevant methods and biomarkers to detect cellular senescence in hepatic stellate cells.
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