化学
沸石
磷酸盐
吸附
核化学
无机化学
生物化学
有机化学
催化作用
作者
Rimsha Batool,Batool Fatima,Fahmida Jabeen,Dilshad Hussain,Muhammad Imran,Muhammad Najam-ul-Haq
出处
期刊:Heliyon
[Elsevier]
日期:2023-05-01
卷期号:9 (5): e16098-e16098
被引量:1
标识
DOI:10.1016/j.heliyon.2023.e16098
摘要
Phosphorylated metabolites are linked to metabolism, and the dysregulation of metabolic reactions brings cancer. Dysregulated levels lead to hyperactivation of glycolytic and mitochondrial oxidative phosphorylation pathways. Abnormal concentrations are the indicators of energy-related disorders. In this work, Zeolite-loaded Mg–Al–Ce hydroxides ([email protected]) are prepared by co-precipitation and characterized through FTIR, XRD, SEM, BET, AFM, TEM, and DLS. Magnesium–Aluminum–Cerium-Zeolite particles enrich phosphate-containing small molecules. These ternary hydroxides carried out the main adsorption mechanism, which swapped the surface hydroxyl group ligands for phosphate and the inner-sphere complex of CePO4. XH2O. Cerium plays a significant role in the complexation of phosphate, and adding Mg and Al further helps disperse Ce and increase the surface charge on the adsorbent. ΑTP and AMP are the standard molecules for parameter optimization. [email protected] enriches phosphorylated metabolites followed by their desorption via UV–vis spectrophotometry. MS profiles for healthy and lung cancer serum samples are obtained for phosphorylated metabolites. Characteristic phosphorylated metabolites have been detected in lung cancer samples with high expression. The role of phosphorylated metabolites is explored for abnormal metabolic pathways in lung cancer. The fabricated material is sensitive, selective, and highly enriched for identifying phosphate-specific biomarkers.
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