药物输送
药品
重新调整用途
药物重新定位
毒品携带者
药理学
脑组织
药物输送到大脑
靶向给药
神经科学
纳米技术
医学
生物
血脑屏障
生物医学工程
材料科学
中枢神经系统
生态学
作者
Purva Khare,Sara X. Edgecomb,Christine M. Hamadani,Eden E. L. Tanner,Devika S. Manickam
标识
DOI:10.1016/j.addr.2023.114861
摘要
Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech and Moderna COVID-19 mRNA vaccines. While LNPs have been extensively studied for the delivery of RNA drugs to muscle and liver targets, their potential to deliver drugs to challenging tissue targets such as the brain remains underexplored. Multiple brain disorders currently lack safe and effective therapies and therefore repurposing LNPs could potentially be a game changer for improving drug delivery to cellular targets both at and across the blood–brain barrier (BBB). In this review, we will discuss (1) the rationale and factors involved in optimizing LNPs for brain delivery, (2) ionic liquid-coated LNPs as a potential approach for increasing LNP accumulation in the brain tissue and (3) considerations, open questions and potential opportunities in the development of LNPs for delivery to the brain.
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