放射肿瘤学
医学
临床肿瘤学
医学物理学
临床试验
肿瘤科
放射治疗
内科学
癌症
作者
Zachary S. Zumsteg,Siddharth Sheth,Salma K. Jabbour,Krishnan R. Patel,Randall J. Kimple,Terence M. Williams,Meng Xu‐Welliver,Pedro A. Torres‐Saavedra,Arta M. Monjazeb,Jyoti Mayadev,Steven E. Finkelstein,John M. Buatti,Sandip Pravin Patel,Steven H. Lin
标识
DOI:10.1016/s1470-2045(24)00264-x
摘要
NRG Oncology's Developmental Therapeutics and Radiation Therapy Subcommittee assembled an interdisciplinary group of investigators to address barriers to successful early phase clinical trials of novel combination therapies involving radiation. This Policy Review elucidates some of the many challenges associated with study design for early phase trials combining radiotherapy with novel systemic agents, which are distinct from drug-drug combination development and are often overlooked. We also advocate for potential solutions that could mitigate or eliminate some of these barriers, providing examples of specific clinical trial designs that could help facilitate efficient and effective evaluation of novel drug-radiotherapy combinations.
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