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Changes of cerebral structure and perfusion in subtypes of systemic sclerosis: a brain magnetic resonance imaging study

医学 磁共振成像 灌注扫描 功能磁共振成像 灌注 病理 心脏病学 内科学 核磁共振 放射科 物理
作者
Xinyu Tong,Huilin He,Shihan Xu,Rui Shen,Zihan Ning,Xiaofeng Zeng,Qian Wang,Zuo-Xiang He,Dong Xu,Xihai Zhao
出处
期刊:Rheumatology [Oxford University Press]
被引量:2
标识
DOI:10.1093/rheumatology/keae404
摘要

Abstract Objectives The characteristics of brain impairment in different subtypes of systemic sclerosis (SSc) (dcSSc, diffuse cutaneous SSc; lcSSc, limited cutaneous SSc) remain unclear. This study aimed to characterize cerebral structure and perfusion changes in different subtypes of SSc patients using magnetic resonance (MR) imaging. Methods Seventy SSc patients (46.0 ± 11.7 years, 62 females) and 30 healthy volunteers (44.8 ± 13.7 years, 24 females) were recruited and underwent brain MR imaging and Montreal Cognitive Assessment (MoCA) test. Gray matter (GM) volumes were measured using voxel-based morphometry analysis on T1-weighted images. Voxel-based and regional cerebral blood flow (CBF) was calculated on arterial spin labelling images. The cerebral structural and perfusion measurements by MR imaging were compared among dcSSc, lcSSc and healthy subjects using one-way ANOVA. The correlations between clinical characteristics and MR imaging measurements were also analysed. Results The dcSSc patients exhibited a significant reduction in GM volume in the para-hippocampal region (cluster P < 0.01, FWE corrected) compared with healthy volunteers. Whereas SSc patients, particularly lcSSc patients, showed elevated CBF in cerebellum, insula, cerebral cortex and subcortical structures (regional analyses: all P < 0.05; voxel-based analyses: cluster P < 0.01, FWE corrected). Furthermore, clinical characteristics of modified Rodnan skin score (mRSS) (r value ranged from −0.29 to −0.45), MoCA scores (r = 0.40) and anti-nuclear antibody (ANA) positivity (r = −0.33) were significantly associated with CBF in some regions (all P < 0.05). Conclusion The manifestations of brain involvement vary among different subtypes of SSc. In addition, severe skin sclerosis may indicate higher risk of brain involvement in SSc patients.
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