化学
金鸡纳
磷化氢
结合
生物碱
酰胺
催化作用
金鸡纳生物碱
有机化学
组合化学
立体化学
对映选择合成
数学分析
数学
作者
Kosei Miyake,Akane Iwamura,Kazuki Fujita,Tsunayoshi Takehara,Takeyuki Suzuki,Naoki Yasukawa,Shuichi Nakamura
标识
DOI:10.1021/acs.orglett.4c02643
摘要
Chiral phosphine-containing amino acids are useful motifs in pharmaceutical compounds. In this study, we developed the asymmetric conjugate addition of phosphine sulfides with α-substituted β-nitroacrylates to synthesize phosphine-containing amino acid precursors with chiral tetrasubstituted carbon centers. This method showed a wide substrate scope, and the obtained products were converted into various chiral compounds. The origin of the enantioselectivity was clarified by computational analysis.
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