Low methyl-esterified ginseng homogalacturonan pectins promote longevity of Caenorhabditis elegans via impairing insulin/IGF-1 signalling

秀丽隐杆线虫 人参 长寿 胰岛素 化学 胰岛素受体 果胶 生物化学 生物 药理学 医学 内分泌学 基因 遗传学 胰岛素抵抗 替代医学 病理
作者
Jiayi Wang,Yuan Wang,Xuejiao Xu,Chengcheng Song,Yuwei Zhou,Dongxue Xue,Zhangkai Feng,Yifa Zhou,Xiaoxue Li
出处
期刊:Carbohydrate Polymers [Elsevier]
卷期号:346: 122600-122600
标识
DOI:10.1016/j.carbpol.2024.122600
摘要

Panax ginseng C. A. Meyer (ginseng) is a medicinal plant widely used for promoting longevity. Recently, homogalacturonan (HG) domain-rich pectins purified from some plants have been reported to have anti-aging-related activities, leading us to explore the longevity-promoting activity of the HG pectins from ginseng. In this study, we discovered that two of low methyl-esterified ginseng HG pectins (named as WGPA-2-HG and WGPA-3-HG), whose degree of methyl-esterification (DM) was 16 % and 8 % respectively, promoted longevity in Caenorhabditis elegans. Results showed that WGPA-2-HG/WGPA-3-HG impaired insulin/insulin-like growth factor 1 (IGF-1) signalling (IIS) pathway, thereby increasing the nuclear accumulation of transcription factors SKN-1/Nrf2 and DAF-16/FOXO and enhancing the expression of relevant anti-aging genes. BLI and ITC analysis showed that the insulin-receptor binding, the first step to activate IIS pathway, was impeded by the engagement of WGPA-2-HG/WGPA-3-HG with insulin. By chemical modifications, we found that high methyl-esterification of WGPA-2-HG/WGPA-3-HG was detrimental for their longevity-promoting activity. These findings provided novel insight into the precise molecular mechanism for the longevity-promoting effect of ginseng pectins, and suggested a potential to utilize the ginseng HG pectins with appropriate DM values as natural nutrients for increasing human longevity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
玩命的毛衣完成签到 ,获得积分10
刚刚
youngk完成签到 ,获得积分10
刚刚
FancyShi发布了新的文献求助10
1秒前
Singularity应助自信的紫青采纳,获得10
2秒前
QYW发布了新的文献求助30
2秒前
orixero应助踏雪无痕采纳,获得10
3秒前
CodeCraft应助爱笑的大白菜采纳,获得10
5秒前
5秒前
5秒前
vanilla完成签到,获得积分10
6秒前
陈博士完成签到,获得积分10
7秒前
Emily完成签到,获得积分10
7秒前
马东完成签到,获得积分10
10秒前
在水一方应助qiiq1997采纳,获得10
10秒前
bluefire完成签到,获得积分10
11秒前
11秒前
vetXue发布了新的文献求助10
11秒前
Erick爱喝粥完成签到,获得积分10
12秒前
机智依丝发布了新的文献求助10
12秒前
13秒前
小小王发布了新的文献求助10
13秒前
14秒前
英俊的铭应助慕辰采纳,获得10
16秒前
啦啦啦发布了新的文献求助10
17秒前
zrz完成签到,获得积分10
17秒前
18秒前
18秒前
ahaaa发布了新的文献求助10
19秒前
19秒前
天天快乐应助激情的一斩采纳,获得10
19秒前
欢喜的代容完成签到,获得积分10
20秒前
隐形之玉完成签到,获得积分10
20秒前
21秒前
NexusExplorer应助mml采纳,获得10
21秒前
lhy完成签到,获得积分10
22秒前
五香完成签到 ,获得积分10
22秒前
樂事发布了新的文献求助10
24秒前
25秒前
xingzou完成签到,获得积分10
25秒前
25秒前
高分求助中
Sustainability in Tides Chemistry 2800
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Handbook of Qualitative Cross-Cultural Research Methods 600
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3137423
求助须知:如何正确求助?哪些是违规求助? 2788470
关于积分的说明 7786719
捐赠科研通 2444666
什么是DOI,文献DOI怎么找? 1300018
科研通“疑难数据库(出版商)”最低求助积分说明 625731
版权声明 601023