创伤性脑损伤
神经炎症
酪氨酸羟化酶
脂质过氧化
医学
多巴胺转运体
药理学
多巴胺
炎症
氧化应激
内科学
多巴胺能
精神科
作者
Sergio Modafferi,Francesco Molinari,Livia Interdonato,Roberta Fusco,Daniela Impellizzeri,Rosalba Siracusa,Ramona D’Amico,Ali S. Abdelhameed,Uwe Wenzel,U. Jacobs,Tilman Fritsch,Naomi Osakabe,Salvatore Cuzzocrea,Vittorio Calabrese,Rosanna Di Paola,Marika Cordaro
摘要
Background/Aims: High Monomeric Polyphenols Berries Extract (HMPBE) is a formula highly rich in polyphenols clinically proven to enhance learning and memory. It is currently used to enhances cognitive performance including accuracy, working memory and concentration. Methods: Here, we investigated for the first time the beneficial effects of HMPBE in a mouse model of acute and chronic traumatic brain injury (TBI). Results: HMPBE, at the dose of 15 mg/kg was able to reduce histological alteration as well as inflammation and lipid peroxidation. HMPBE ameliorate TBI by improving Nrf-2 pathway, reducing Nf-kb nuclear translocation and apoptosis, and ameliorating behavioral alteration such as anxiety and depression. Moreover, in the chronic model of TBI, HMPBE administration restored the decline of Tyrosine Hydroxylase (TH) and dopamine transporter (DAT) and the accumulation of a-synuclein into the midbrain region. This finding correlates the beneficial effect of HMPBE administration with the onset of parkinsonism related to traumatic brain damage. Conclusion: The data may open a window for developing new support strategies to limit the neuroinflammation event of acute and chronic TBI.
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