Understanding the role of ten-eleven translocation family proteins in kidney diseases

表观遗传学 染色体易位 DNA甲基化 DNA去甲基化 染色质 5-羟甲基胞嘧啶 生物 信使核糖核酸 表观基因组 抑制因子 5-甲基胞嘧啶 DNA 染色质重塑 基因 甲基化 遗传学 基因表达
作者
Yuelin Zhang,Jiahui Li,Li Tan,Jun Xue,Yujiang Geno Shi
出处
期刊:Biochemical Society Transactions [Portland Press]
卷期号:52 (5): 2203-2214
标识
DOI:10.1042/bst20240291
摘要

Epigenetic mechanisms play a critical role in the pathogenesis of human diseases including kidney disorders. As the erasers of DNA methylation, Ten-eleven translocation (TET) family proteins can oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), thus leading to passive or active DNA demethylation. Similarly, TET family proteins can also catalyze the same reaction on RNA. In addition, TET family proteins can also regulate chromatin structure and gene expression in a catalytic activity-independent manner through recruiting the SIN3A/HDAC co-repressor complex. In 2012, we reported for the first time that the genomic 5-hydroxymethylcytosine level and the mRNA levels of Tet1 and Tet2 were significantly downregulated in murine kidneys upon ischemia and reperfusion injury. Since then, accumulating evidences have eventually established an indispensable role of TET family proteins in not only acute kidney injury but also chronic kidney disease. In this review, we summarize the upstream regulatory mechanisms and the pathophysiological role of TET family proteins in major types of kidney diseases and discuss their potential values in clinical diagnosis and treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI5应助呜呜采纳,获得10
刚刚
刚刚
1秒前
等待静枫完成签到,获得积分10
1秒前
peterlu完成签到,获得积分10
1秒前
orixero应助Ir采纳,获得10
1秒前
感谢zhang转发科研通微信,获得积分50
1秒前
华仔应助ZJX采纳,获得10
2秒前
徐嘎嘎完成签到,获得积分10
4秒前
健壮丹妗完成签到 ,获得积分10
4秒前
华仔应助深情的路灯采纳,获得50
5秒前
5秒前
酱er发布了新的文献求助30
5秒前
等待秋尽发布了新的文献求助10
6秒前
123完成签到,获得积分10
6秒前
大个应助科研通管家采纳,获得10
6秒前
英俊的铭应助科研通管家采纳,获得10
7秒前
情怀应助科研通管家采纳,获得10
7秒前
7秒前
田様应助科研通管家采纳,获得10
7秒前
思源应助科研通管家采纳,获得10
7秒前
Jasper应助科研通管家采纳,获得30
7秒前
永远55度完成签到,获得积分10
7秒前
科研通AI5应助科研通管家采纳,获得10
7秒前
隐形曼青应助科研通管家采纳,获得10
7秒前
FashionBoy应助科研通管家采纳,获得10
7秒前
图图应助科研通管家采纳,获得100
7秒前
搜集达人应助科研通管家采纳,获得10
7秒前
wanci应助科研通管家采纳,获得10
7秒前
感谢奋斗平卉转发科研通微信,获得积分50
7秒前
山花浪漫应助科研通管家采纳,获得10
7秒前
7秒前
Jasper应助科研通管家采纳,获得10
8秒前
完美世界应助严笑容采纳,获得30
8秒前
8秒前
trayheep应助科研通管家采纳,获得10
8秒前
8秒前
科研通AI5应助科研通管家采纳,获得10
8秒前
情怀应助科研通管家采纳,获得10
8秒前
8秒前
高分求助中
All the Birds of the World 4000
Production Logging: Theoretical and Interpretive Elements 3000
Les Mantodea de Guyane Insecta, Polyneoptera 2000
Am Rande der Geschichte : mein Leben in China / Ruth Weiss 1500
CENTRAL BOOKS: A BRIEF HISTORY 1939 TO 1999 by Dave Cope 1000
Machine Learning Methods in Geoscience 1000
Resilience of a Nation: A History of the Military in Rwanda 888
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3737633
求助须知:如何正确求助?哪些是违规求助? 3281316
关于积分的说明 10024435
捐赠科研通 2998032
什么是DOI,文献DOI怎么找? 1645003
邀请新用户注册赠送积分活动 782459
科研通“疑难数据库(出版商)”最低求助积分说明 749814