外胚层
诱导多能干细胞
胚胎干细胞
原肠化
细胞生物学
内细胞团
胚泡
生物
干细胞
胚芽层
胚状体
胚胎
遗传学
胚胎发生
基因
作者
Mitsuhiro Endoh,Hitoshi Niwa
标识
DOI:10.15252/embr.202255010
摘要
Abstract Pluripotent cells in mouse embryos, which first emerge in the inner cell mass of the blastocyst, undergo gradual transition marked by changes in gene expression, developmental potential, polarity, and morphology as they develop from the pre‐implantation until post‐implantation gastrula stage. Recent studies of cultured mouse pluripotent stem cells (PSCs) have clarified the presence of intermediate pluripotent stages between the naïve pluripotent state represented by embryonic stem cells (ESCs—equivalent to the pre‐implantation epiblast) and the primed pluripotent state represented by epiblast stem cells (EpiSCs—equivalent to the late post‐implantation gastrula epiblast). In this review, we discuss these recent findings in light of our knowledge on peri‐implantation mouse development and consider the implications of these new PSCs to understand their temporal sequence and the feasibility of using them as model system for pluripotency.
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