Pathogenesis and research progress of diabetes and cognitive impairment

With the improvement of quality of life and the acceleration of aging process of population, the prevalence of diabetes in adults in china is increasing, and the group of patients with diabetes combined with cognitive dysfunction is expanding. At present, diabetes combined with cognitive impairment is gradually becoming a hot issue of worldwide concern. In this paper, the pathogenesis of diabetes combined with cognitive dysfunction is described from the following aspects: metabolic abnormalities, cerebrovascular disease, inflammatory mediators, neurotrophic factor deficiency, blood-cerebrospinal fluid barrier dysfunction, hypothalamic-pituitary-adrenal axis hyperfunction, and activation of renin-angiotensin system.