Preserving the activity of attenuating atherosclerosis of nattokinase in gastrointestinal system by NK/SA/CS microcapsules

纳豆激酶 胃液 壳聚糖 体内 化学 口服 体外 药理学 海藻酸钠 脂肪组织 医学 生物化学 色谱法 生物 发酵 生物技术 有机化学
作者
Minghao Xie,Meilian Yang,Zhenyu Wang,Shuzhen Cheng,Ming Du
出处
期刊:Food bioscience [Elsevier BV]
卷期号:59: 103949-103949 被引量:2
标识
DOI:10.1016/j.fbio.2024.103949
摘要

The study focused on the role of Nattokinase/Sodium alginate/Chitosan microcapsules (NK/SA/CS microcapsules) in preserving nattokinase activity in the gastrointestinal system and attenuating atherosclerosis . The thrombolytic activity of NK would normally be lost in acidic gastric fluid after oral administration. To address this issue, the researchers developed a novel delivery system using alginate- and chitosan-encapsulated microcapsules. The NK/SA/CS microcapsules protected the loaded NK from deactivation by gastric fluid, as demonstrated by in vitro and in vivo tests. The NK/SA/CS microcapsules retained 80.41% enzyme activity in simulated gastric fluid and 50.69% in the gastric content of mice after 2 h. In atherosclerosis models, the NK/SA/CS microcapsules were found to reduce body weight and epididymal adipose weight in mice. Furthermore, they effectively managed the progression of atherosclerosis and significantly improved the lipid profile . Overall, the study highlights the potential of the NK/SA/CS microcapsules as a delivery system for NK, protecting its activity in the presence of gastric fluid and demonstrating positive therapeutic effects regarding weight management and atherosclerosis progression. Note: An electrostatic spraying device was used to form NK/SA/CS microcapsules. The NK/SA/CS microcapsules protected the loaded NK from damage by gastric fluid, as demonstrated by in vitro and in vivo tests. The NK/SA/CS microcapsules reduced the weight of mice, regulated blood lipid levels, and alleviated atherosclerosis symptoms. • Optimization of nattokinase fermentation conditions by response surface methodology. • The microcapsules protected nattokinase from deactivation by gastric fluid. • The microcapsules effectively managed the progression of atherosclerosis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
FleeToMars完成签到 ,获得积分10
刚刚
在水一方应助dongdong采纳,获得10
1秒前
1秒前
萧萧发布了新的文献求助10
2秒前
bkagyin应助GQL采纳,获得10
3秒前
4秒前
上官若男应助牛牛牛采纳,获得10
4秒前
量子星尘发布了新的文献求助10
5秒前
Hello应助萧萧采纳,获得10
6秒前
嗖_啪_发布了新的文献求助10
7秒前
8秒前
pipipi完成签到,获得积分10
8秒前
9秒前
小熊猫发布了新的文献求助10
10秒前
Adenine完成签到 ,获得积分10
10秒前
lililili关注了科研通微信公众号
11秒前
deletelzr完成签到,获得积分10
12秒前
12秒前
牛牛牛发布了新的文献求助10
15秒前
16秒前
17秒前
djiwisksk66应助松松老师采纳,获得10
19秒前
Alice完成签到,获得积分10
20秒前
学术小牛发布了新的文献求助10
20秒前
djiwisksk66应助ll采纳,获得10
21秒前
22秒前
24秒前
26秒前
28秒前
29秒前
31秒前
31秒前
2896186249发布了新的文献求助10
32秒前
33秒前
xiaofeiyan发布了新的文献求助20
34秒前
唠叨的以柳完成签到,获得积分20
36秒前
陈骏康发布了新的文献求助10
37秒前
37秒前
rnf发布了新的文献求助10
38秒前
38秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971516
求助须知:如何正确求助?哪些是违规求助? 3516229
关于积分的说明 11181488
捐赠科研通 3251405
什么是DOI,文献DOI怎么找? 1795821
邀请新用户注册赠送积分活动 876051
科研通“疑难数据库(出版商)”最低求助积分说明 805245