抗菌活性
配体(生物化学)
组合化学
金黄色葡萄球菌
化学
聚合物
立体化学
有机化学
生物
细菌
生物化学
受体
遗传学
作者
Ziyun Wang,Lun Zhao,Hongwei Jing,Guanying Song,Jiayu Li
出处
期刊:Molecules
[MDPI AG]
日期:2024-04-26
卷期号:29 (9): 1990-1990
标识
DOI:10.3390/molecules29091990
摘要
As the use of antibiotics increases, the increasing resistance of bacteria is the main reason for the reduced efficiency of antibacterial drugs, making the research of new antibacterial materials become new hot spot. In this article, two novel coordination polymers (CPs), namely, [Cd2(L)2(bibp)2]n (1) and [Ni(L)(bib)]n (2), where H2L = N,N′-bis(4-carbozvlbenzvl)-4-aminotoluene, bibp = 4,4′-bis(imidazol-1-yl)biphenyl, and bib = 1,3-bis(1-imidazoly)benzene, have been synthesized under solvothermal and hydrothermal condition. Structural clarification was performed through infrared spectrum and single-crystal X-ray diffraction analysis, while thermal analysis and XRD technology were used for the performance assessment of compounds 1 and 2. In addition, antibacterial performance experiments showed that compounds 1 and 2 have certain selectivity in their antibacterial properties and have good antibacterial properties against S. aureus. As the concentration of the compound increases, the inhibitory effect gradually strengthens, and when the concentration of the compound reaches 500 μg/mL and 400 μg/mL, the concentration of the S. aureus solution no longer increases and has been completely inhibited.
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