Targeting metalloimmunology via a nanoenabled approach to effectively treating solid tumors

The significance of metals in activating antitumoral immune responses has sparked widespread interest. In this issue of Chem, Bao et al. present preclinical success with ethylenediaminetetraacetate-loaded layered double hydroxide (EDTA/LDH) nanoparticles, which are capable of stimulating antitumoral immune reactions and promoting the infiltration of immune cells into solid tumors by inducing calcium deprivation.