小胶质细胞
神经病理性疼痛
免疫系统
巨噬细胞
炎症
神经炎症
发病机制
平衡
医学
中枢神经系统
脊髓
免疫学
神经科学
病理
生物
内科学
体外
生物化学
作者
Ying Ye,Hao Cheng,Yan Wang,Yan Sun,Lidong Zhang,Jun Tang
标识
DOI:10.1080/08830185.2024.2344170
摘要
Research on the relationship between macrophages and neuropathic pain has flourished in the past two decades. It has long been believed that macrophages are strong immune effector cells that play well-established roles in tissue homeostasis and lesions, such as promoting the initiation and progression of tissue injury and improving wound healing and tissue remodeling in a variety of pathogenesis-related diseases. They are also heterogeneous and versatile cells that can switch phenotypically/functionally in response to the micro-environment signals. Apart from microglia (resident macrophages of both the spinal cord and brain), which are required for the neuropathic pain processing of the CNS, neuropathic pain signals in PNS are influenced by the interaction of tissue-resident macrophages and BM infiltrating macrophages with primary afferent neurons. And the current review looks at new evidence that suggests sexual dimorphism in neuropathic pain are caused by variations in the immune system, notably macrophages, rather than the neurological system.
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