亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Angiographic Coronary Slow Flow Is Not a Valid Surrogate for Invasively Diagnosed Coronary Microvascular Dysfunction

医学 蒂米 冠状动脉血流储备 心脏病学 内科学 部分流量储备 溶栓 心肌梗塞 冠状动脉 冠状动脉循环 冠状动脉疾病 动脉 血流 冠状动脉造影
作者
M. Mayer,Tess Allan,Kenneth L. Harkin,Ethan Loftspring,Seyed Ehsan Saffari,Harmony R. Reynolds,Jonathan Paul,Rohan Kalathiya,Atman P. Shah,Sandeep Nathan,Mary C. McCarthy,Nathaniel R. Smilowitz,Steven E.S. Miner,John D. Blair
出处
期刊:Jacc-cardiovascular Interventions [Elsevier]
卷期号:17 (7): 920-929 被引量:4
标识
DOI:10.1016/j.jcin.2024.02.025
摘要

Ischemia with no obstructive coronary arteries is frequently caused by coronary microvascular dysfunction (CMD). Consensus diagnostic criteria for CMD include baseline angiographic slow flow by corrected TIMI (Thrombolysis In Myocardial Infarction) frame count (cTFC), but correlations between slow flow and CMD measured by invasive coronary function testing (CFT) are uncertain. The aim of this study was to investigate relationships between cTFC and invasive CFT for CMD. Adults with ischemia with no obstructive coronary arteries underwent invasive CFT with thermodilution-derived baseline coronary blood flow, coronary flow reserve (CFR), and index of microcirculatory resistance (IMR). CMD was defined as abnormal CFR (<2.5) and/or abnormal IMR (≥25). cTFC was measured from baseline angiography; slow flow was defined as cTFC >25. Correlations between cTFC and baseline coronary flow and between CFR and IMR and associations between slow flow and invasive measures of CMD were evaluated, adjusted for covariates. All patients provided consent. Among 508 adults, 49% had coronary slow flow. Patients with slow flow were more likely to have abnormal IMR (36% vs 26%; P = 0.019) but less likely to have abnormal CFR (28% vs 42%; P = 0.001), with no difference in CMD (46% vs 51%). cTFC was weakly correlated with baseline coronary blood flow (r = −0.35; 95% CI: −0.42 to −0.27), CFR (r = 0.20; 95% CI: 0.12 to 0.28), and IMR (r = 0.16; 95% CI: 0.07-0.24). In multivariable models, slow flow was associated with lower odds of abnormal CFR (adjusted OR: 0.53; 95% CI: 0.35 to 0.80). Coronary slow flow was weakly associated with results of invasive CFT and should not be used as a surrogate for the invasive diagnosis of CMD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
边城小子完成签到,获得积分10
13秒前
23秒前
lbjcp3发布了新的文献求助10
26秒前
SciGPT应助lbjcp3采纳,获得30
52秒前
迷你的靖雁完成签到,获得积分10
1分钟前
1分钟前
1分钟前
从容芮完成签到,获得积分0
1分钟前
lbjcp3发布了新的文献求助30
1分钟前
1分钟前
林非鹿完成签到,获得积分10
1分钟前
AJoe发布了新的文献求助10
1分钟前
1分钟前
小蘑菇应助AJoe采纳,获得10
1分钟前
去去去去发布了新的文献求助10
2分钟前
Woo_SH完成签到 ,获得积分10
2分钟前
田様应助去去去去采纳,获得10
2分钟前
子月之路完成签到,获得积分10
2分钟前
2分钟前
奇凌发布了新的文献求助10
2分钟前
Joe发布了新的文献求助30
2分钟前
奇凌完成签到,获得积分10
2分钟前
2分钟前
3分钟前
athena发布了新的文献求助10
3分钟前
李家静完成签到 ,获得积分10
3分钟前
3分钟前
清脆冥幽完成签到,获得积分20
4分钟前
FashionBoy应助lbjcp3采纳,获得30
4分钟前
4分钟前
4分钟前
小巫发布了新的文献求助10
4分钟前
4分钟前
4分钟前
zhangxr发布了新的文献求助10
4分钟前
4分钟前
桐桐应助科研通管家采纳,获得30
4分钟前
Simon应助科研通管家采纳,获得10
4分钟前
爆米花应助科研通管家采纳,获得10
4分钟前
lbjcp3发布了新的文献求助30
4分钟前
高分求助中
The Oxford Handbook of Social Cognition (Second Edition, 2024) 1050
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Handbook of Qualitative Cross-Cultural Research Methods 600
Chen Hansheng: China’s Last Romantic Revolutionary 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3139573
求助须知:如何正确求助?哪些是违规求助? 2790430
关于积分的说明 7795287
捐赠科研通 2446905
什么是DOI,文献DOI怎么找? 1301487
科研通“疑难数据库(出版商)”最低求助积分说明 626238
版权声明 601146