Angiographic Coronary Slow Flow Is Not a Valid Surrogate for Invasively Diagnosed Coronary Microvascular Dysfunction

医学 蒂米 冠状动脉血流储备 心脏病学 内科学 部分流量储备 溶栓 心肌梗塞 冠状动脉 冠状动脉循环 冠状动脉疾病 动脉 血流 冠状动脉造影
作者
M. Mayer,Tess Allan,Kenneth L. Harkin,Ethan Loftspring,Seyed Ehsan Saffari,Harmony R. Reynolds,Jonathan Paul,Rohan Kalathiya,Atman P. Shah,Sandeep Nathan,Mary C. McCarthy,Nathaniel R. Smilowitz,Steven E.S. Miner,John D. Blair
出处
期刊:Jacc-cardiovascular Interventions [Elsevier BV]
卷期号:17 (7): 920-929 被引量:8
标识
DOI:10.1016/j.jcin.2024.02.025
摘要

Ischemia with no obstructive coronary arteries is frequently caused by coronary microvascular dysfunction (CMD). Consensus diagnostic criteria for CMD include baseline angiographic slow flow by corrected TIMI (Thrombolysis In Myocardial Infarction) frame count (cTFC), but correlations between slow flow and CMD measured by invasive coronary function testing (CFT) are uncertain. The aim of this study was to investigate relationships between cTFC and invasive CFT for CMD. Adults with ischemia with no obstructive coronary arteries underwent invasive CFT with thermodilution-derived baseline coronary blood flow, coronary flow reserve (CFR), and index of microcirculatory resistance (IMR). CMD was defined as abnormal CFR (<2.5) and/or abnormal IMR (≥25). cTFC was measured from baseline angiography; slow flow was defined as cTFC >25. Correlations between cTFC and baseline coronary flow and between CFR and IMR and associations between slow flow and invasive measures of CMD were evaluated, adjusted for covariates. All patients provided consent. Among 508 adults, 49% had coronary slow flow. Patients with slow flow were more likely to have abnormal IMR (36% vs 26%; P = 0.019) but less likely to have abnormal CFR (28% vs 42%; P = 0.001), with no difference in CMD (46% vs 51%). cTFC was weakly correlated with baseline coronary blood flow (r = −0.35; 95% CI: −0.42 to −0.27), CFR (r = 0.20; 95% CI: 0.12 to 0.28), and IMR (r = 0.16; 95% CI: 0.07-0.24). In multivariable models, slow flow was associated with lower odds of abnormal CFR (adjusted OR: 0.53; 95% CI: 0.35 to 0.80). Coronary slow flow was weakly associated with results of invasive CFT and should not be used as a surrogate for the invasive diagnosis of CMD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
初初见你完成签到,获得积分10
5秒前
8秒前
思源应助淡淡月饼采纳,获得20
8秒前
dd完成签到 ,获得积分10
9秒前
Nayvue发布了新的文献求助10
13秒前
未来的幻想完成签到,获得积分10
15秒前
Kvolu29完成签到,获得积分10
16秒前
长理物电强完成签到,获得积分10
17秒前
若安在完成签到,获得积分10
18秒前
完美世界应助潘特采纳,获得10
19秒前
拼搏问薇完成签到 ,获得积分10
19秒前
单薄乐珍完成签到 ,获得积分0
22秒前
张静枝完成签到 ,获得积分10
22秒前
六步郎完成签到,获得积分10
22秒前
啊怙纲完成签到 ,获得积分10
24秒前
量子星尘发布了新的文献求助10
26秒前
scott_zip完成签到 ,获得积分10
27秒前
gxl完成签到,获得积分0
31秒前
xxx完成签到 ,获得积分10
34秒前
34秒前
努力生活的小柴完成签到,获得积分10
36秒前
38秒前
tangyong完成签到,获得积分10
40秒前
长安发布了新的文献求助10
40秒前
SucceedIn完成签到,获得积分10
41秒前
42秒前
45秒前
海洋岩土12138完成签到 ,获得积分10
46秒前
lzz完成签到 ,获得积分10
46秒前
冬雪完成签到,获得积分10
50秒前
woommoow完成签到,获得积分10
50秒前
aaatan完成签到 ,获得积分10
50秒前
lynn完成签到,获得积分10
51秒前
ABC发布了新的文献求助10
51秒前
回忆完成签到,获得积分10
52秒前
溜了溜了完成签到,获得积分10
55秒前
萧水白完成签到,获得积分10
57秒前
马桶盖盖子完成签到 ,获得积分10
57秒前
漆漆漆漆漆完成签到,获得积分10
59秒前
xzy998应助科研通管家采纳,获得10
59秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038184
求助须知:如何正确求助?哪些是违规求助? 3575908
关于积分的说明 11373872
捐赠科研通 3305715
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022