One–Pot Assembly of 2‐Trifluoromethyl Benzothiazole and Benzoselenazole via Copper–Mediated Three–Component Cascade Reaction

Abstract A domino one–pot synthesis of 2‐(trifluoromethyl) benzothiazole via copper–mediated three–component cascade reaction starting from the easily accessible starting materials such as o ‐iodoanilines, methyl trifluoropyruvate, and elemental sulfur is reported. The present strategy displayed a comprehensive substrate scope and good functional group tolerance and enabled access to a variety of substituted 2‐(trifluoromethyl) benzothiazoles. A 2‐(trifluoromethyl) benzoselenazole has also been synthesized utilizing this reaction methodology.