Revealing gut microbiome associations with CFS

The etiology of chronic fatigue syndrome (CFS) is largely unknown. In this issue of Cell Host and Microbe, Guo et al. and Xiong et al. report CFS-associated gut microbiome and metabolomic datasets-implicating dysregulation of immune modulating molecules. This may provide a framework for new therapeutic paradigms and disease origins. The etiology of chronic fatigue syndrome (CFS) is largely unknown. In this issue of Cell Host and Microbe, Guo et al. and Xiong et al. report CFS-associated gut microbiome and metabolomic datasets-implicating dysregulation of immune modulating molecules. This may provide a framework for new therapeutic paradigms and disease origins. Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patientsXiong et al.Cell Host & MicrobeFebruary 08, 2023In BriefME/CFS is an understudied multisystemic disease. Xiong et al. present an integrated multi-‘omics analysis comparing ME/CFS patients with matched controls. Short-term disease was characterized by greater gut microbial dysbiosis, particularly a depletion of butyrate-producing microbes; long-term disease was associated with more severe phenotypic and metabolic abnormalities. Full-Text PDF Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFSGuo et al.Cell Host & MicrobeFebruary 08, 2023In BriefThe metagenomic analysis of Guo et al. reveals extensive gut microbiome dysbiosis in patients with myalgic encephalomyelitis/chronic fatigue syndrome and uncovers differences in species abundance, function, and ecological interactions. Reduced abundance of Faecalibacterium prausnitzii is associated with butyrate deficiency and symptom severity, providing insights into the functional consequences of dysbiosis. Full-Text PDF Open Access