Microvascular Dysfunction Associates With Outcomes in Hypertrophic Cardiomyopathy: Insights From the Intravoxel Incoherent MotionMRI

Background Although intravoxel incoherent motion (IVIM) MRI has emerged as an in vivo marker of tissue diffusion and perfusion, its prognostic value in patients with hypertrophic cardiomyopathy (HCM) remains unclear. Purpose To investigate whether IVIM‐MRI derived parameters are associated with outcomes in patients with HCM. Study Type Prospective cohort. Subjects A total of 112 patients (51.72 ± 17.13 years) with suspected or known HCM. Field Strength/Sequence Single‐shot echo planar IVIM imaging, balanced steady‐state free precession, and phase‐sensitive inversion‐recovery late gadolinium enhancement (LGE) sequences at 3 T. Assessment All patients were followed up of 29.3 ± 12.3 months for combined major adverse cardiac events (MACE) including cardiac death, aborted sudden death, heart transplantation, and rehospitalization for heart failure. The CVI42 imaging platform was used to assess morphological and functional MRI indices and to quantify LGE. The Body Diffusion Toolbox was used to derive pseudo diffusion (D*), water molecular diffusion (D) and perfusion fraction (f). Statistical Tests Univariable and stepwise multivariable Cox model analyses were used to investigate the association between variables and composite endpoints. Kaplan–Meier curves were constructed to assess event‐free survival, and the event rates were compared by the log‐rank test. Results A total of 19 patients reached endpoints. Patients with MACE showed a significantly impaired D* value, lower f value, and more extensive LGE than those without MACE (all, P < 0.05), while there was no significant difference in D value ( P = 0.285). In the Cox regression models, D* value (hazard ratio [HR] 0.93; 95% CI: 0.88–0.98) and f value (HR 0.65; 95% CI: 0.45–0.92) were independent predictors for MACE. Moreover, in Kaplan–Meier survival analysis, the incidence of MACE was significantly higher in patients with decreased D* value and f value. Conclusions Impaired D* and f values derived from IVIM‐MRI are associated with adverse outcomes in patients with HCM. Level of Evidence 2 Technical Efficacy Stage 2