Weaning causes imbalanced T lymphocyte distribution and impaired intestinal immune barrier function in piglets

断奶 免疫系统 生物 势垒函数 淋巴细胞 免疫学 淋巴细胞亚群 动物科学 T细胞 细胞生物学
作者
Dong Li,Mengxuan Wang,Zhong Peng,Hongmin Li,Hongrong Wang,Tao Qin,Yinyan Yin,Lihuai Yu
出处
期刊:Animal Production Science [CSIRO Publishing]
卷期号:64 (2)
标识
DOI:10.1071/an22471
摘要

Context The immune system of piglets is not fully developed at weaning. The immature adaptive immune system along with the change in the feed types and the living conditions make piglets susceptible to pathogenic infections, and result in diarrhoea and decreased growth. However, the underlying mechanisms require further research. Aims This study was conducted to investigate the effects of weaning on the growth performance and intestinal immune function of piglets. Methods In total, 40 piglets with similar bodyweights were selected in pairs at 21 days old and divided into the suckling group (SG, breastfed by their mothers) and weaning group (WG, weaned at 21 days old). Eight piglets from each group were randomly selected and sacrificed at 24 days (SG3 and WG3) and 28 days of age (SG7 and WG7). The growth performance, T lymphocyte subpopulations, the concentration of cytokines and immunoglobulins, and the expression of Notch2 signalling proteins were determined. Key results The weaning caused a decrease in bodyweight (P < 0.01) and the ratio of CD3+CD4+/CD3+CD8+ T cells in the thymus (P < 0.05). Compared with SG3, the concentration of secretory immunoglobulin A (sIgA) in the jejunum was decreased, and that of interleukin 2 (IL-2) in serum and ileum, IL-1β and IL-2 in jejunum were upregulated (P < 0.01), while IL-10 in the small intestine was downregulated (P < 0.05) in WG3. Weaning downregulated gene expression of IL-4 and upregulated gene expression of IL-1β, IL-12, and interferon γ (IFN-γ) in small intestine (P < 0.05). Weaning downregulated protein expression of Notch2 and Hes1 but upregulated Jagged1 expression in small intestine of piglets (P < 0.05). Conclusions Weaning caused an imbalance in T lymphocyte distribution, thus impairing the intestinal immune function of piglets, which might be associated with the Notch2 signalling. Furthermore, weaning caused adverse effects on piglets especially on the first 3 days, which were partly recovered after 3 days, but still existed at 7 days after weaning. Implications The results of this study may guide the pig-raising industry, especially for the management of piglets shortly after weaning.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
liangmh完成签到,获得积分10
1秒前
一二不休完成签到,获得积分10
1秒前
123发布了新的文献求助10
2秒前
4秒前
ding应助黑熊安巴尼采纳,获得10
5秒前
Ava应助wjxcl采纳,获得10
5秒前
闪闪如南发布了新的文献求助10
5秒前
深情安青应助一二不休采纳,获得10
6秒前
8秒前
123完成签到,获得积分10
8秒前
不扯先生完成签到,获得积分10
9秒前
柳絮完成签到,获得积分20
10秒前
lll完成签到,获得积分10
10秒前
sdl完成签到,获得积分10
10秒前
Orange应助孟婆的碗采纳,获得10
11秒前
zhangmy1989发布了新的文献求助30
11秒前
11秒前
清秀的不言完成签到 ,获得积分10
11秒前
杂化轨道退役研究员完成签到,获得积分10
11秒前
FashionBoy应助tanglu采纳,获得10
12秒前
13秒前
闪闪如南完成签到,获得积分10
14秒前
wjxcl完成签到,获得积分10
15秒前
15秒前
15秒前
12233完成签到,获得积分10
16秒前
16秒前
洪武完成签到,获得积分20
16秒前
17秒前
Yuantian发布了新的文献求助10
18秒前
传奇3应助浪花淘尽英雄采纳,获得10
19秒前
流川枫完成签到,获得积分10
19秒前
赘婿应助leo采纳,获得10
19秒前
追寻夏烟完成签到 ,获得积分10
20秒前
闪闪寒云完成签到 ,获得积分10
20秒前
13633501455完成签到 ,获得积分10
21秒前
阿里完成签到,获得积分10
21秒前
蓁蓁发布了新的文献求助10
22秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048