氮原子
氮气
吡啶
点突变
Atom(片上系统)
碳纤维
碳原子
点(几何)
化学
突变
材料科学
药物化学
有机化学
数学
戒指(化学)
计算机科学
基因
生物化学
并行计算
几何学
复合数
复合材料
作者
Nicholas Falcone,Si-Rong He,John Hoskin,Sandeep Mangat,Erik J. Sorensen
标识
DOI:10.26434/chemrxiv-2024-2jvms
摘要
Single-atom editing has emerged as a powerful process for altering molecular structures with precision. Within this growing class of transformations, reactions that replace one atom for another in heterocycles, while desirable, remain limited. We report the development of a transformation that achieves an N-to-C atom swap in pyridine N-oxides utilizing a sulfoxide-derived anion as a carbon source. This ‘point mutation’ exhibits good functional group tolerance and replaces the N-oxide moiety with either unsubstituted, substituted, or isotopically labeled carbon atoms in a single laboratory operation.
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