Photobiomodulation Therapy to Treat Snakebites Caused by Bothrops atrox

医学 随机对照试验 低强度激光治疗 肌酸激酶 抗蛇毒血清 环境化 外科 麻醉 激光治疗 毒液 内科学 激光器 生态学 物理 光学 生物
作者
Érica da Silva Carvalho,Andrea Renata do Nascimento Souza,Dessana Francis Chehuan Melo,Altair Seabra de Farias,Bruna Barbosa de Oliveira Macedo,Marco Aurélio Sartim,Mariela Costa Caggy,Beatriz de Alcântara Rodrigues,Gabriela Salini Ribeiro,Heloísa Nunes Reis,Felipe Queiroz Araújo,Iran Mendonça da Silva,André Sachett,Vanderson de Souza Sampaio,Antônio Alcirley da Silva Balieiro,Stella Regina Zamunér,João Ricardo Nickenig Vissoci,Lioney Nobre Cabral,Wuelton Marcelo Monteiro,Jacqueline de Almeida Gonçalves Sachett
出处
期刊:JAMA Internal Medicine [American Medical Association]
卷期号:184 (1): 70-70 被引量:4
标识
DOI:10.1001/jamainternmed.2023.6538
摘要

Importance Bothrops venom acts almost immediately at the bite site and causes tissue damage. Objective To investigate the feasibility and explore the safety and efficacy of low-level laser therapy (LLLT) in reducing the local manifestations of B atrox envenomations. Design, Setting, and Participants This was a double-blind randomized clinical trial conducted at Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, in Manaus, Brazil. A total of 60 adult participants were included from November 2020 to March 2022, with 30 in each group. Baseline characteristics on admission were similarly distributed between groups. Data analysis was performed from August to December 2022. Intervention The intervention group received LLLT combined with regular antivenom treatment. The laser used was a gallium arsenide laser with 4 infrared laser emitters and 4 red laser emitters, 4 J/cm 2 for 40 seconds at each application point. Main Outcomes and Measures Feasibility was assessed by eligibility, recruitment, and retention rates; protocol fidelity; and patients’ acceptability. The primary efficacy outcome of this study was myolysis estimated by the value of creatine kinase (U/L) on the third day of follow-up. Secondary efficacy outcomes were (1) pain intensity, (2) circumference measurement ratio, (3) extent of edema, (4) difference between the bite site temperature and that of the contralateral limb, (5) need for the use of analgesics, (6) frequency of secondary infections, and (7) necrosis. These outcomes were measured 48 hours after admission. Disability assessment was carried out from 4 to 6 months after patients’ discharge. P values for outcomes were adjusted with Bonferroni correction. Results A total of 60 patients (mean [SD] age, 43.2 [15.3] years; 8 female individuals [13%] and 52 male individuals [87%]) were included. The study was feasible, and patient retention and acceptability were high. Creatine kinase was significantly lower in the LLLT group (mean [SD], 163.7 [160.0] U/L) 48 hours after admission in relation to the comparator (412.4 [441.3] U/L) ( P = .03). Mean (SD) pain intensity (2.9 [2.7] vs 5.0 [2.4]; P = .004), circumference measurement ratio (6.6% [6.6%] vs 17.1% [11.6%]; P < .001), and edema extent (25.9 [15.0] vs 45.9 [24.7] cm; P = .002) were significantly lower in the LLLT group in relation to the comparator. No difference was observed between the groups regarding the mean difference between the bite site temperature and the contralateral limb. Secondary infections, necrosis, disability outcomes, and the frequency of need for analgesics were similar in both groups. No adverse event was observed. Conclusions and Relevance The data from this randomized clinical trial suggest that the use of LLLT was feasible and safe in a hospital setting and effective in reducing muscle damage and the local inflammatory process caused by B atrox envenomations. Trial Registration Brazilian Registry of Clinical Trials Identifier: RBR-4qw4vf
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