亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy

医学 相对风险 随机对照试验 置信区间 怀孕 子痫前期 坦桑尼亚 入射(几何) 产科 活产 内科学 遗传学 环境科学 物理 环境规划 光学 生物
作者
Pratibha Dwarkanath,Alfa Muhihi,Christopher R. Sudfeld,Blair J. Wylie,Molin Wang,Nandita Perumal,Tinku Thomas,Shabani Kinyogoli,Mohamed Bakari,Ryan Fernandez,John-Michael Raj,Ndeniria Swai,Nirmala Buggi,R Shobha,Mary M. Sando,Christopher Duggan,Honorati Masanja,Anura V. Kurpad,Andrea B. Pembe,Wafaie Fawzi
出处
期刊:The New England Journal of Medicine [Massachusetts Medical Society]
卷期号:390 (2): 143-153 被引量:13
标识
DOI:10.1056/nejmoa2307212
摘要

BackgroundThe World Health Organization recommends 1500 to 2000 mg of calcium daily as supplementation, divided into three doses, for pregnant persons in populations with low dietary calcium intake in order to reduce the risk of preeclampsia. The complexity of the dosing scheme, however, has led to implementation barriers.MethodsWe conducted two independent randomized trials of calcium supplementation, in India and Tanzania, to assess the noninferiority of a 500-mg daily dose to a 1500-mg daily dose of calcium supplementation. In each trial, the two primary outcomes were preeclampsia and preterm birth, and the noninferiority margins for the relative risks were 1.54 and 1.16, respectively.ResultsA total of 11,000 nulliparous pregnant women were included in each trial. The cumulative incidence of preeclampsia was 3.0% in the 500-mg group and 3.6% in the 1500-mg group in the India trial (relative risk, 0.84; 95% confidence interval [CI], 0.68 to 1.03) and 3.0% and 2.7%, respectively, in the Tanzania trial (relative risk, 1.10; 95% CI, 0.88 to 1.36) — findings consistent with the noninferiority of the lower dose in both trials. The percentage of live births that were preterm was 11.4% in the 500-mg group and 12.8% in the 1500-mg group in the India trial (relative risk, 0.89; 95% CI, 0.80 to 0.98), which was within the noninferiority margin of 1.16; in the Tanzania trial, the respective percentages were 10.4% and 9.7% (relative risk, 1.07; 95% CI, 0.95 to 1.21), which exceeded the noninferiority margin.ConclusionsIn these two trials, low-dose calcium supplementation was noninferior to high-dose calcium supplementation with respect to the risk of preeclampsia. It was noninferior with respect to the risk of preterm live birth in the trial in India but not in the trial in Tanzania. (Funded by the Bill and Melinda Gates Foundation and others; ClinicalTrials.gov number, NCT03350516; Clinical Trials Registry–India number, CTRI/2018/02/012119; and Tanzania Medicines and Medical Devices Authority Trials Registry number, TFDA0018/CTR/0010/5).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
迷茫的一代完成签到,获得积分10
54秒前
魔笛的云宝完成签到 ,获得积分10
1分钟前
www完成签到,获得积分10
1分钟前
1分钟前
NexusExplorer应助科研通管家采纳,获得10
2分钟前
Akitten发布了新的文献求助10
2分钟前
啥时候吃火锅完成签到 ,获得积分0
3分钟前
上官若男应助科研通管家采纳,获得30
3分钟前
斯文败类应助科研通管家采纳,获得10
3分钟前
李爱国应助科研通管家采纳,获得10
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
赘婿应助科研通管家采纳,获得10
3分钟前
田様应助精明晓刚采纳,获得10
4分钟前
4分钟前
精明晓刚发布了新的文献求助10
4分钟前
科研通AI2S应助科研通管家采纳,获得10
6分钟前
coolplex完成签到 ,获得积分10
6分钟前
wwe完成签到,获得积分10
6分钟前
貔貅完成签到 ,获得积分10
7分钟前
yindi1991完成签到 ,获得积分10
9分钟前
hgl完成签到,获得积分10
9分钟前
9分钟前
科研通AI2S应助科研通管家采纳,获得10
10分钟前
10分钟前
华仔应助精明晓刚采纳,获得10
10分钟前
10分钟前
11分钟前
精明晓刚发布了新的文献求助10
11分钟前
糖伯虎完成签到 ,获得积分10
11分钟前
在水一方应助科研通管家采纳,获得10
11分钟前
光合作用完成签到,获得积分10
12分钟前
13分钟前
精明晓刚发布了新的文献求助10
13分钟前
精明晓刚完成签到,获得积分10
13分钟前
13分钟前
搜集达人应助kangkang采纳,获得10
13分钟前
英姑应助科研通管家采纳,获得10
13分钟前
kangkang完成签到,获得积分20
14分钟前
14分钟前
刘紫媛发布了新的文献求助10
14分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990351
求助须知:如何正确求助?哪些是违规求助? 3532158
关于积分的说明 11256513
捐赠科研通 3271046
什么是DOI,文献DOI怎么找? 1805207
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234